Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

More Documents

SML3651

Sigma-Aldrich

Deschloroclozapine

≥98% (HPLC)

Synonym(s):

11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, DCZ

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H20N4
CAS Number:
1977-07-7
Molecular Weight:
292.38
MDL number:
MFCD01730958
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Deschloroclozapine (DCZ) is a potent and selective DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) agonist (hM3Dq/hM4Di Ki = 6.3/4.2 nM vs hM3/hM4 Ki = 230/210 nM; hM3Dq/hM4Di EC50 = 130/81 nM by celluar BRET assays) with much greater potency than CNO and C21. DCZ selectively stimulates DREADDs, but not non-DREADDs, cells (Ca2+ EC50 = 2.3 nM/hM3Dq, cAMP IC50 = 0.0048 nM/hM4Di, β-arrestin recruitment EC50 = 0.63 nM/hM3Dq & 0.048 nM/hM4Di). DCZ enhances neuronal activity in hM3Dq mice (1 μg/kg i.p.) & monkeys (1-3 μg/kg i.v.) and induces spatial working memory deficits in hM4Di monkeys (100 μg/kg i.m.) in vivo.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Nicholas A Upright et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(11), 1793-1798 (2020-03-21)
The most common chemogenetic neuromodulatory system, designer receptors exclusively activated by designer drugs (DREADDs), uses a non-endogenous actuator ligand to activate a modified muscarinic acetylcholine receptor that is insensitive to acetylcholine. It is crucial in studies using these systems to
Yuji Nagai et al.
Nature neuroscience, 23(9), 1157-1167 (2020-07-08)
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with clozapine-N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service