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SML3261

Sigma-Aldrich

JS6

≥98% (HPLC)

Synonym(s):

2-(2-Fluorobenzamido)-N-[2-(morpholin-4-yl)ethyl]benzamide, 2-Fluoro-N-(2-(2-morpholinoethylcarbamoyl)phenyl)benzamide, 2-[(2-Fluorobenzoyl)amino]-N-[2-(4-morpholinyl)ethyl]benzamide

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About This Item

Empirical Formula (Hill Notation):
C20H22FN3O3
CAS Number:
950244-33-4
Molecular Weight:
371.41
UNSPSC Code:
12352107
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1NC(C2=C(C=CC=C2)F)=O)NCCN3CCOCC3

Biochem/physiol Actions

JS6 is a Bcl3:NF-kB p50 protein-protein interaction (PPI) inhibitor that effectively suppresses Bcl3-dependent intracellular NF-kB activity (IC50 = 45/159 nM using Bcl3-overexpressing MDA-MB-231/HEK293; IC50 = 710 nM using HEK293 overexpressing Bcl3 and NF-kB p52). JS6 prevents enhanced MDA-MB-231 migration upon Bcl3 overexpression in cultures (IC50 = 310 nM), and effectively suppresses primary tumor growth as well as secondary tumor colonisation in vivo (3.5-10 mg/kg/d i.p. mice with MDA-MB-436 or 4T1.2 murine carcinoma xenograft) without overt systemic toxicity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Jitka Soukupová et al.
Molecular cancer therapeutics, 20(5), 775-786 (2021-03-03)
The development of antimetastatic drugs is an urgent healthcare priority for patients with cancer, because metastasis is thought to account for around 90% of cancer deaths. Current antimetastatic treatment options are limited and often associated with poor long-term survival and

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