Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SML2944

Sigma-Aldrich

Mca-YVADAPK(Dnp)-OH trifluoroacetate

≥97% (HPLC)

Synonym(s):

Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp), TFA salt, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, TFA salt, Mca-YVADAPK(Dnp), TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl)

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C53H64N10O19 · xC2HF3O2
Molecular Weight:
1145.13 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

assay

≥97% (HPLC)

form

film or powder

color

white to dark beige

storage temp.

−20°C

Biochem/physiol Actions

Mca-YVADAPK(Dnp)-OH is a widely used fluorescent substrate for caspase-1 (ICE cleaves between D & A) and angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service