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SML2422

Sigma-Aldrich

Sophocarpine

≥95% (HPLC)

Synonym(s):

(-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O
CAS Number:
6483-15-4
Molecular Weight:
246.35
MDL number:
MFCD00274555
UNSPSC Code:
12352200

biological source

Sophora alopecuroides

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -26 to -35°, c = 0.5 in ethanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1

InChI key

NBBQEIQEBNYSFK-PUILLJIJSA-N

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Biochem/physiol Actions

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Genhuan Yang et al.
Annals of palliative medicine, 9(4), 1622-1630 (2020-06-13)
Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play

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