SML1311

Rubone

≥98% (HPLC)

• Synonym(s): (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one, 2′-Hydroxy-2,4,4′,5,6′-pentamethoxychalcone
• Empirical Formula (Hill Notation): C₂₀H₂₂O₇
• CAS Number: 73694-15-2
• Molecular Weight: 374.38
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow to orange
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• InChI: 1S/C20H22O7/c1-23-13-9-15(22)20(19(10-13)27-5)14(21)7-6-12-8-17(25-3)18(26-4)11-16(12)24-2/h6-11,22H,1-5H3/b7-6+
• InChI key: VHCQVGQULWFQTM-VOTSOKGWSA-N

Description

Biochem/physiol Actions

Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growth, migration and cancer stem-like cells (CSC) population growth.

Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes.

Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable