SBR00031

MIT HCl Ready Made Solution

(10 mg MIT/mL)

• Synonym(s): 2-Methyl-1,2-thiazol-3-one, Methylisothiazolinone HCl, Methylisothiazolinone hydrochloride
• UNSPSC Code: 51102829
• NACRES: NA.76

Properties

• form: liquid
• Quality Level: 200
• concentration: (10 mg MIT/mL); 1%
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• InChI: 1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
• InChI key: SJXPQSRCFCPWQQ-UHFFFAOYSA-N

Description

General description

Methylisothiazolinone, also known as 2-Methyl-4-isothiazolin-3-one, is a potent synthetic biocide and preservative belonging to the group of isothiazolinones. It effectively controls microbial growth and acts as a broad-spectrum antibiotic, similar to the function and performance of bromonitrodioxane. It is effective against both gram-positive and gram-negative bacteria, as well as yeast and fungi. Additionally, it serves as an antifouling biocide, an antimicrobial agent, and an antifungal agent. 2-Methyl-4-isothiazolin-3-one is utilized in cell biology and biochemical applications to effectively prevent the growth of bacterial contaminants, ensuring the purity of cell lines.

Application

Methylisothiazolinone (MIT) has been used:

• in research on the effects of the N-methyl D-aspartate (NMDA) receptor antagonist kynurenic acid on human cortical development
• as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
• to research the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Biochem/physiol Actions

Mode of Action: Inhibits the growth of microorganisms by disrupting the normal function of microbial cells and interfering with essential cellular processes

Activity Spectrum: Active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI)

Features and Benefits

• Ready available solution reduce the need for preparation time
• Commonly used in Cell Biology and Biochemical applications
• High quality antibiotic suitable for mulitple research applications

Other Notes

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Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H317,H319,H412
• pcodes: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable