SAB5700521

Anti-Phospho-PERK-T982 antibody produced in rabbit

• Synonym(s): EIF2AK3, PEK, PERK, WRS
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 125
• species reactivity: mouse, human, rat
• concentration: 1.67 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: Q9NZJ5
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr982)
• Gene Information: human ... EIF2AK3(9451)

Description

General description

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Immunogen

A phospho specific peptide corresponding to residues surrounding T980 of human PERK.

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable