SAB4700662

Monoclonal Anti-HLA-DR-PE antibody produced in mouse

clone MEM-12, purified immunoglobulin, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: phycoerythrin (R-PE) conjugate
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: MEM-12, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): flow cytometry: suitable
• isotype: IgG1
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... HLA-DRA(3122)

Description

General description

Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6. HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes.

The antibody MEM-12 recognizes common epitope on human HLA-DR which is dependent on the association of alpha and beta chains. DR is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Immunogen

Thymocyte membrane

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Biochem/physiol Actions

Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen. Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable