SAB4300411

Anti-BRCA1 (Ab-1524) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
• MDL number: MFCD01092286
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~220 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200
• isotype: IgG
• immunogen sequence: (Y-P-S-Q-E)
• NCBI accession no.: NP_009225.1
• UniProt accession no.: P38398
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... BRCA1(672)

Description

Immunogen

Peptide sequence around aa. 1522-1526 (Y-P-S-Q-E), according to the protein BRCA1.

Features and Benefits

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Target description

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable