BRCA1
breast cancer 1, early onset
Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Species:
Human BRCA1 (672), Mouse Brca1 (12189), Rat Brca1 (497672), Thale Cress BRCA1 (827854), domestic cat BRCA1 (493761), cow BRCA1 (353120), Horse BRCA1 (100051990), domestic cat BRCA1 (101081937), dog BRCA1 (403437), chicken BRCA1 (373983) ...More
UniProtKB ID:
Gene ID:
- Human(672) Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
- Mouse(12189) breast cancer 1
- Rat(497672) breast cancer 1, early onset
- Thale Cress(827854) protein BREAST CANCER SUSCEPTIBILITY 1-like protein
- domestic cat(493761) breast cancer 1, early onset
- cow(353120) breast cancer 1, early onset
- Horse(100051990) breast cancer 1, early onset
- domestic cat(101081937) breast cancer 1, early onset
- dog(403437) breast cancer 1, early onset
- chicken(373983) breast cancer 1, early onset
- naked mole-rat(101705460) breast cancer 1, early onset
- domestic guinea pig(100722339) breast cancer 1, early onset
- sheep(101108584) breast cancer 1, early onset
- Domestic Rabbit(100347269) breast cancer 1, early onset
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-BRCA1 (pSer1457) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-BRCA1 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-BRCA1 Antibody, clone MS13, clone MS13, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-BRCA1 (Ab-4) Mouse mAb (SD118), liquid, clone SD118, Calbiochem®,
Species Reactivity
human
Application
Anti-BRCA1 (Ab-1) Mouse mAb (MS110), liquid, clone MS110, Calbiochem®,
Species Reactivity
human
Application
Kits
Product Number
Description
Species
CpG WIZ™ BRCA1 -Methylation specific PCR assay, Methylation-specific PCR (MSP), performed using the CpGenome DNA Modification Kit & the CpG WIZ BRCA1 Amplification Kit, permits sensitive detection of altered DNA.,
Species
human