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RAB0659

Sigma-Aldrich

Human FOLR1 / Folate Receptor Alpha ELISA Kit

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.84

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.1 ng/mL
standard curve range: 0.102-25 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FOLR1(2348)

General description

The antibody pair provided in this kit recognizes human Folate Receptor Alpha.
The folate receptor 1 (FOLR1) gene is mapped to human chromosome 11q13.4. The gene codes for a glycosylphosphatidylinositol protein that is attached to cell membranes. Folr1 is expressed in placenta, kidney tubules and choroid plexus.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Folate receptor 1 (FOLR1) plays a vital role in folate transport across the blood–brain barrier through the choroid plexus. It is also essential for neural tube closure during embryogenesis. Mutation in the gene leads to the development of cerebral folate deficiency in a few families. Overexpression of the gene has been observed in some epithelial malignancies including medulloblastoma, ovarian, lung and breast carcinomas. FOLR1 acts as a potential biomarker and therapeutic target for medulloblastoma.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8B - Non-combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Differential expression of folate receptor 1 in medulloblastoma and the correlation with clinicopathological characters and target therapeutic potential.
Liu H, et al.
Oncotarget, 8(14), 23048-23048 (2017)
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Watkins D and Rosenblatt DS
Journal of inherited metabolic disease, 35(4), 665-670 (2012)
Congenital null mutations of the FOLR1 gene: a progressive neurologic disease and its treatment.
Cario H, et al.
Neurology, 73(24), 2127-2129 (2009)

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