PZ0171

CP-100356 monohydrochloride

>98% (HPLC), powder, MDR1 (P-Gp) inhibitor

• Synonym(s): 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride
• Empirical Formula (Hill Notation): C₃₁H₃₆N₄O₆ · HCl
• CAS Number: 142715-48-8
• Molecular Weight: 597.10
• MDL number: MFCD00911858
• UNSPSC Code: 12161501
• PubChem Substance ID: 329823745
• NACRES: NA.77

Properties

• product name: CP-100356 monohydrochloride, >98% (HPLC)
• assay: >98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC
• InChI: 1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H
• InChI key: WWCHXVYTCMPAMV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC₅₀ >15 mM).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable