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Key Documents

PLA0057

Sigma-Aldrich

Rabbit anti-Mre11 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

AT-like disease, ATLD, DNA recombination and repair protein, HNGS1, MRE11, MRE11 double strand break repair nuclease A, MRE11 homolog, MRE11 homolog 1, MRE11 homolog A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 meiotic recombination 11-like protein A, MRE11B, double strand break repair nuclease A, endo/exonuclease Mre11, meiotic recombination (S. cerevisiae) 11 homolog A, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

technique(s)

immunohistochemistry: 1:1,000-1:5,000
western blot: 1:1,000- 1:5,000

accession no.

NP_005582.1

UniProt accession no.

P49959

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... Mre11(4361)

Immunogen

The epitope recognized by PLA0057 maps to a region between residues 1 and 50 of human Meiotic Recombination 11 homolog A using the numbering given in entry NP_005582.1 (GeneID 4361).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3′– 5′ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mariko Tsukagoshi et al.
Oncotarget, 8(26), 42159-42172 (2017-02-09)
Cholangiocarcinoma is a highly malignant tumor, and the development of new therapeutic strategies is critical. Karyopherin-α2 (KPNA2) functions as an adaptor that mediates nucleocytoplasmic transport. Specifically, KPNA2 transports one of the important DNA repair machineries, the MRE11-RAD50-NBS1 (MRN) complex, to
Beeke Wienert et al.
Science (New York, N.Y.), 364(6437), 286-289 (2019-04-20)
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct detection in vivo. We developed DISCOVER-Seq (discovery of in situ
Rebecca M Martin et al.
Oncotarget, 5(4), 993-1003 (2014-03-15)
Predictive assays are needed to help optimise treatment in muscle-invasive bladder cancer, where patients can be treated by either cystectomy or radical radiotherapy. Our finding that low tumour MRE11 expression is predictive of poor response to radiotherapy but not cystectomy
Bárbara Alcaraz Silva et al.
The Journal of biological chemistry, 289(33), 22771-22784 (2014-07-02)
Chromosome ends contain nucleoprotein structures known as telomeres. Damage to chromosome ends during interphase elicits a DNA damage response (DDR) resulting in cell cycle arrest. However, little is known regarding the signaling from damaged chromosome ends (designated here as "TIPs")

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