P1537
Polyadenylic acid-Polyuridylic acid sodium salt
double-stranded homopolymer
Synonym(s):
Poly[A]•Poly[U]
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About This Item
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Quality Level
form
powder
storage temp.
−20°C
InChI
1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
InChI key
VGQHQOKIMNKUEF-ZLOOHWKQSA-N
Application
Polyadenylic acid-Polyuridylic acid (polyAU) is a double stranded homodimer studied for potential therapeutic activity, especially when coupled with radiotherapy. PolyA/U is used in comparative physiochemical studies with other duplex and single-stranded polymers such as poly-A and poly-U.
Other Notes
Double stranded homopolymer
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis.
E D Madraso et al.
Immunology, 35(1), 77-84 (1978-07-01)
Nino Lomadze et al.
Organic & biomolecular chemistry, 4(9), 1755-1759 (2006-04-25)
The affinities of polyamines consisting of ethylenediamine units equipped with either one or two terminal naphthyl-, anthryl-, or acridyl units towards PolyA.PolyU as an RNA model, and Poly(dA).Poly(dT) as a DNA model are screened by measuring the melting point changes
Tarita Biver et al.
Nucleic acids research, 38(5), 1697-1710 (2009-12-17)
The interaction of coralyne with poly(A)*poly(U), poly(A)*2poly(U), poly(A) and poly(A)*poly(A) is analysed using spectrophotometric, spectrofluorometric, circular dichroism (CD), viscometric, stopped-flow and temperature-jump techniques. It is shown for the first time that coralyne induces disproportionation of poly(A)*poly(U) to triplex poly(A)*2poly(U) and
H-C Jeung et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 19(3), 520-526 (2007-11-22)
This phase III trial was to compare 5-fluorouracil (5-FU), adriamycin, and polyadenylic-polyuridylic acid (poly A:U) against 5-fluorouracil plus adriamycin (FA) for operable gastric cancer. From 1984 to 1989, patients who had D(2-3) curative resection were randomly assigned to receive chemotherapy
W Pohle et al.
Biopolymers, 67(6), 499-503 (2002-09-05)
We used FTIR spectroscopy to comparatively study the hydration of films prepared from nucleic acids (DNA and double-stranded RNA) and lipids (phosphatidylcholines and phosphatidylethanolamines chosen as the most abundant ones) at room temperature by varying the ambient relative humidity in
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