O7889

Anti-OMP antibody produced in rabbit

~2 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Olfactory Marker Protein
• MDL number: MFCD09265364
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~19 kDa
• species reactivity: rat, mouse
• concentration: ~2 mg/mL
• technique(s): western blot: 0.5-1.0 μg/mL using rat brain (olfactory bulb) extract (S1 fraction).
• UniProt accession no.: P08523
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: rat ... Omp(24612)

Description

General description

Olfactory marker protein (OMP) is a phylogenetically conserved cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. OMP is expressed in both the olfactory neuroepithelium and the olfactory nerve projection to the olfactory bulb. In perikaryon, OMP is produced and are transported to the dendrite and axon in the glomerular layer of the olfactory bulb.

Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

Immunogen

synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH.

Application

Anti-OMP antibody produced in rabbit has been used in immunohistochemistry.

Anti-OMP antibody produced in rabbit has been used in:

• immunoblotting
• double immunofluorescence
• staining

Biochem/physiol Actions

Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)