M0639

6α-Methylprednisolone

≥98%

• Synonym(s): 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, Medrone
• Empirical Formula (Hill Notation): C₂₂H₃₀O₅
• CAS Number: 83-43-2
• Molecular Weight: 374.47
• Beilstein/REAXYS Number: 2340300
• EC Number: 201-476-4
• MDL number: MFCD00010591
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896564
• NACRES: NA.77

Properties

• biological source: synthetic
• sterility: non-sterile
• assay: ≥98%
• form: powder
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• application(s): cell analysis
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
• InChI key: VHRSUDSXCMQTMA-PJHHCJLFSA-N
• Gene Information: human ... NR3C1(2908) ; rat ... Nr3c1(24413)

Description

Application

6α-Methylprednisolone has been used:

• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
• to induce depletion of CD14⁺ CD16⁺ monocytes
• to study its effect on behavioral and sensory afferent hypersensitivity

Biochem/physiol Actions

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2
• target_organs: Adrenal gland,Immune system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• ppe: Eyeshields, Gloves, type N95 (US)