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Key Documents

C4980

Sigma-Aldrich

Anti-Calcium Channel (Cardiac α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD02095952
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rabbit, rat

technique(s)

immunoprecipitation (IP): suitable
western blot (chemiluminescent): suitable

UniProt accession no.

P15381

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Cacna1c(24239)

Immunogen

N-terminal residues 1-46 of rabbit cardiac type α1C subunit fused to GST.

Physical form

Lyophilized from PBS, pH 7.4, containing 1% BSA, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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E Shistik et al.
The Journal of biological chemistry, 274(44), 31145-31149 (1999-10-26)
The first 46 amino acids (aa) of the N terminus of the rabbit heart (RH) L-type cardiac Ca(2+) channel alpha(1C) subunit are crucial for the stimulating action of protein kinase C (PKC) and also hinder channel gating (Shistik, E., Ivanina
A Mikami et al.
Nature, 340(6230), 230-233 (1989-07-20)
In cardiac muscle, where Ca2+ influx across the sarcolemma is essential for contraction, the dihydropyridine (DHP)-sensitive L-type calcium channel represents the major entry pathway of extracellular Ca2+. We have previously elucidated the primary structure of the rabbit skeletal muscle DHP
Bruno Barcellos Jacobsen et al.
Arquivos brasileiros de cardiologia, 109(5), 432-439 (2017-10-27)
Different types of high-fat and/or high-energy diets have been used to induce obesity in rodents. However, few studies have reported on the effects observed at the initial stage of obesity induced by high-fat feeding on cardiac functional and structural remodelling.
G P Miljanich et al.
Annual review of pharmacology and toxicology, 35, 707-734 (1995-01-01)
This article reviews the structural and functional diversity of neuronal calcium channels and the therapeutic potential of antagonizing such channels. Through spatial and temporal control of intracellular calcium concentration, voltage-sensitive calcium channels regulate a host of neuronal processes, including neurotransmitter
H Moreno Davila
Annals of the New York Academy of Sciences, 868, 102-117 (1999-07-22)
The contributing roles of voltage-gated calcium channels (VGCC) to the generation of electrical signaling are well documented. VGCCs open in response to depolarization of the plasma membrane and mediate the flux of calcium into excitable cells, which further depolarizes the
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