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C3011

Sigma-Aldrich

Cesium chloride

Grade I, ≥99.0%

Synonym(s):

Caesium monochloride, Cesium chloride

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About This Item

Linear Formula:
CsCl
CAS Number:
7647-17-8
Molecular Weight:
168.36
EC Number:
231-600-2
MDL number:
MFCD00010955
UNSPSC Code:
12352207
PubChem Substance ID:
57653999
NACRES:
NA.75

type

Grade I

Quality Level

100

assay

≥99.0%

form

powder

mp

645 °C (lit.)

absorption

≤0.2 at 280 in H2O at 50%

application(s)

hematology
histology

SMILES string

[Cl-].[Cs+]

InChI

1S/ClH.Cs/h1H;/q;+1/p-1

InChI key

AIYUHDOJVYHVIT-UHFFFAOYSA-M

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Application

Cesium chloride has been used as a component of pipette solution, to record mechanosensitive currents in dorsal root ganglia neurons. It has been used in patch clamping to study neurons in intact myenteric ganglia.
Used for the preparation of electrically conducting glasses.Used to make solutions for the separation of RNA from DNA by density gradient centrifugation.

Biochem/physiol Actions

Oral intake of cesium chloride is known to increase the pH in cancer cells. Mild toxicity of cesium chloride might cause hypotension, gastrointestinal distress, numbness and syncope. It also leads to severe hypokalemia, hypomagnesemia, acute heart attack and polymorphic ventricular tachycardia in episodes.

Quality

Solutions may contain a slight haze.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361f

Hazard Classifications

Repr. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator
Jizhe H, et al.
Nature Protocols, 6(7), 979-979 (2011)
Patch clamp recording from enteric neurons in situ
Nancy O, et al.
Nature Protocols, 6(1), 15-15 (2011)
Petr Melnikov et al.
Biological trace element research, 135(1-3), 1-9 (2009-08-06)
The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However
Piotr Jurkiewicz et al.
Biochimica et biophysica acta, 1818(3), 609-616 (2011-12-14)
Effects of alkali metal chlorides on the properties of mixed negatively charged lipid bilayers are experimentally measured and numerically simulated. Addition of 20mol% of negatively charged phosphatidylserine to zwitterionic phosphatidylcholine strengthens adsorption of monovalent cations revealing their specificity, in the
Therese Abrahamsson et al.
Neuron, 73(6), 1159-1172 (2012-03-27)
Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within neuronal circuits is largely unknown. We studied the spatiotemporal profile of synaptic integration and short-term plasticity in dendrites of mature cerebellar
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