Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

C2917

Sigma-Aldrich

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

Synonym(s):

α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C166H274N46O53S2
CAS Number:
99658-03-4
Molecular Weight:
3826.36
MDL number:
MFCD00081543
UNSPSC Code:
51111800
NACRES:
NA.32

Quality Level

200

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

Gene Information

human ... CRH(1392)
mouse ... CRH(12918)
rat ... CRH(81648)

Looking for similar products? Visit Product Comparison Guide

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

S Y Cheng et al.
Neuroscience, 169(1), 236-245 (2010-04-27)
This study was focused on determining the possible role of corticotropin-releasing hormone (CRH) on play fighting in juvenile golden hamsters. As no specific neural sites have been proposed, we looked for changes in CRH innervations at the peak of play-fighting
Ricardo Borges Machado et al.
International journal of endocrinology, 2010, 326151-326151 (2010-07-16)
Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pituitary-adrenal axis and increased corticotropin-releasing hormone (CRH) impairs sleep. The purpose of the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service