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Key Documents

B8556

Sigma-Aldrich

Hemocyanin from mollusk

buffered aqueous solution

Synonym(s):

Blue Carrier®

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About This Item

CAS Number:
9013-72-3
MDL number:
MFCD00131280
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

Concholepas sp. (Concholepas concholepas )

Quality Level

200

form

buffered aqueous solution

technique(s)

bioconjugation: suitable

storage temp.

2-8°C

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Application

Blue Carrier is an oxygen-carrying protein isolated from the hemolymph of the mollusk Concholepas concholepas. It is highly immunogenic, useful as a carrier protein for the production of antibodies to small molecules. An example of the protocol is given in reference to production of antibodies to gizzerosine.
Hemocyanin is a carrier protein used in antibody production. It has been used to promote antibody production against haptins and peptides, in therepy for bladder carcinoma, and has a component in vaccines for cancer.

Biochem/physiol Actions

Highly soluble carrier protein used in antibody production

Physical form

100 mg in 0.5 mL of 0.15 M NaCl, 0.1 M sodium phosphate, pH 7.2

Legal Information

Blue Carrier is a registered trademark of Biosonda S.A.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Harold Oliva et al.
Hybridoma and hybridomics, 21(5), 365-374 (2002-12-10)
We studied the reactivity of mouse monoclonal antibodies (MAbs) against the hemocyanin from the Chilean marine gastropod Concholepas concholepas (CCH). This protein has been successfully used as a carrier to produce antibodies to haptens and peptides. All MAbs (13) belonging
M I Becker et al.
Hybridoma, 17(4), 373-381 (1998-10-28)
This study is the first report of the development of monoclonal antibodies (MAbs) against gizzerosine (GZ), one of the causative agents of black vomit, a serious poultry disease. Balb/c mice were immunized with different GZ conjugates; the most immunogenic conjugate
Bruno Moltedo et al.
The Journal of urology, 176(6 Pt 1), 2690-2695 (2006-11-07)
We determined the antitumor properties of a newly available hemocyanin obtained from the Chilean gastropod Concholepas concholepas (Biosonda Corp., Santiago, Chile) in a syngeneic heterotopic mouse bladder carcinoma model. Since keyhole limpet hemocyanin (Pierce, Rockford, Illinois) is used increasingly in
Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects.
Arancibia S., et al.
European Journal of Immunology (2011)
Anaphylaxis caused by hemocyanin contained in shrimp cephalothorax.
Daiana Guillen et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(6), 674-675 (2014-10-14)
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