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73881

Sigma-Aldrich

Fluo 3-AM

≥90% (TLC)

Synonym(s):

4-(6-Acetoxymethoxy-2,7-dichloro-3-oxo-9-xanthenyl)-4′-methyl-2,2′(ethylenedioxy)dianiline-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl) ester

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About This Item

Empirical Formula (Hill Notation):
C51H50Cl2N2O23
CAS Number:
121714-22-5
Molecular Weight:
1129.85
UNSPSC Code:
12352200
NACRES:
NA.32

Quality Level

100

assay

≥90% (TLC)

form

powder

fluorescence

λex 506 nm; λem 525 nm in 0.1 M Tris pH 8.0, esterase

storage temp.

−20°C

SMILES string

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc2cc(ccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C3=C4C=C(Cl)C(=O)C=C4Oc5cc(OCOC(C)=O)c(Cl)cc35

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Application

Cell permeable fluorescent indicator of intracellular Ca2+; non-fluorescent until it is hydrolyzed intracellularly and/or in the presence of Ca2+; lower binding affinity allows measurement of higher peaks of Ca2+ transients than with Fura 2.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Hong-zhu Li et al.
Journal of biomedical science, 18, 18-18 (2011-02-18)
Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues. However, the roles of dopamine D2 receptors in myocardial ischemia/reperfusion injury and cardiomyocyte apoptosis are unclear. Here we

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