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Key Documents

358R-1

Sigma-Aldrich

MUM1 (EP190) Rabbit Monoclonal Primary Antibody

Synonym(s):

Multiple Myeloma Oncogene-1

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP190, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (358R-14)
vial of 0.1 mL concentrate Research Use Only (358R-14-RUO)
vial of 0.5 mL concentrate (358R-15)
vial of 1.0 mL concentrate (358R-16)
vial of 1.0 mL concentrate Research Use Only (358R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (358R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (358R-17)
vial of 7.0 mL pre-dilute ready-to-use (358R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (358R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

diffuse large B-cell (lymphoma), plasma cell myeloma (tumor), tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, nuclear

Gene Information

human ... PWWP3A(84939)

Related Categories

General description

Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene. It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas). MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL). Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma. However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive. MUM1 is also expressed in plasma cell myeloma.

Quality


IVD
IVD
IVD
RUO

Linkage

MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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W Kempf et al.
The British journal of dermatology, 158(6), 1280-1287 (2008-04-16)
Primary cutaneous CD30+ lymphoproliferative disorders include lymphomatoid papulosis (LyP) and primary cutaneous CD30+ anaplastic large T-cell lymphoma (ALCL). Because of overlapping histological features, it is impossible to distinguish ALCL from LyP on histological grounds. MUM1 (Multiple Myeloma oncogene 1) is
Antonino Carbone et al.
British journal of haematology, 117(2), 366-372 (2002-04-26)
Biological and clinical studies have shown that Hodgkin's disease (HD) can be divided into two major categories, termed nodular lymphocyte predominance HD (NLP HD) and classic HD (CHD). Within CHD four subtypes have been distinguished: nodular sclerosis, mixed cellularity, lymphocyte
Christine P Hans et al.
Blood, 103(1), 275-282 (2003-09-25)
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like (GCB), activated B-cell-like (ABC), and type 3 gene expression profiles using a cDNA microarray. Tissue microarray (TMA) blocks were created from 152 cases of
Uma Sundram et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 16(8), 802-810 (2003-08-16)
The diagnosis of malignant melanoma remains one of the most difficult to render in surgical pathology, partially because of its extreme histologic variability. Limits in the sensitivity and/or specificity of the currently available melanocytic markers such as anti-S100, HMB45, and

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