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Key Documents

336R-9

Sigma-Aldrich

Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-40, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (336R-94)
vial of 0.5 mL concentrate (336R-95)
bottle of 1.0 mL predilute (336R-97)
vial of 1.0 mL concentrate (336R-96)
bottle of 7.0 mL predilute (336R-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

pancreas

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... SYP(6855)

General description

Anti-synaptophysin reacts with neuroendocrine cells of the human adrenal medulla, pituitary,thyroid, lung, pancreas, and gastrointestinal mucosa. Positive staining is seen in neuronsof the brain. This antibody identifies normal neuroendocrine cells and neuroendocrineneoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probablycorrelates with the distribution of the antigen within neurosecretory vesicles. Antisynaptophysin is an independent, broad-range marker of neural and neuroendocrinedifferentiation.

Quality


IVD
IVD
IVD
RUO

Linkage

Synaptophysin Positive Control Slides , Product No. 336S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Michael G Conner et al.
Annals of diagnostic pathology, 6(6), 345-348 (2002-12-13)
Twenty-three patients with primary small cell carcinoma of the uterine cervix are presented. Their ages ranged between 23 and 63 years (average, 43 years). Blood spotting or vaginal bleeding was the most common clinical presentation. Histologically, the tumors were densely
B Wiedenmann et al.
Cell, 41(3), 1017-1028 (1985-07-01)
A polypeptide of Mr 38,000 has been identified as a specific component of the membrane of presynaptic vesicles, using the monoclonal antibody SY38. This protein, which is acidic (isoelectric at approximately pH 4.8) and glycosylated, appears to be an integral
M Skacel et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 203-209 (2000-09-12)
Histologic differential diagnosis of acinar cell carcinoma (ACC), mixed acinar-endocrine cell carcinoma (MAEC), and pancreatic endocrine tumors (PET) can be difficult but is important because of differences in their clinical behavior. This study investigates the utility of immunohistochemistry (IHC) in
Eun-Ik Son et al.
Pathology international, 53(2), 67-73 (2003-02-18)
Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non-anaplastic, four diffuse/anaplastic, three nodular/non-anaplastic and one
F Navone et al.
The Journal of cell biology, 103(6 Pt 1), 2511-2527 (1986-12-01)
An intrinsic membrane protein of brain synaptic vesicles with Mr 38,000 (p38, synaptophysin) has recently been partially characterized (Jahn, R., W. Schiebler, C. Ouimet, and P. Greengard, 1985, Proc. Natl. Acad. Sci. USA, 83:4137-4141; Wiedenmann, B., and W. W. Franke
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