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Key Documents

260M-1

Sigma-Aldrich

Glycophorin A (GA-R2) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

GA-R2, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (260M-14)
vial of 0.5 mL concentrate (260M-15)
bottle of 1.0 mL predilute (260M-17)
vial of 1.0 mL concentrate (260M-16)
bottle of 7.0 mL predilute (260M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2bκ

control

bone marrow

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... GYPA(2993)

General description

Glycophorins A (GPA) and B (GPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and SU blood groups. Glycophorins span the membrane and present their amino-terminal end to the extracellular surface of the human erythrocyte. The genetic array of expressed glycophorin surface antigens on erythrocytes defines the blood group phenotype of the individual. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion thus minimizing aggregation between red blood cells in the circulation. Anti-glycophorin A has been used to characterize erythroid cell development and in the diagnosis of erythroid leukemias.
Glycophorins A and B are major sialoglycoproteins expressed across the surface of the human erythrocyte membrane and contain the antigenic determinants that define the MNS blood group system. The high sialic acid content of glycophorin A contributes to the generation of a net negative surface charge across erythrocyte membranes that minimizes interactions between red blood cells and prevents their aggregation. Anti-glycophorin A has utility in identifying cells of the erythroid lineage.

Quality


IVD
IVD
IVD
RUO

Linkage

Glycophorin A Positive Control Slides, Product No. 260S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Y Sadahira et al.
Journal of clinical pathology, 52(12), 919-921 (2000-03-11)
To investigate whether spectrin can be used as an immunohistochemical marker for erythroid precursors in routinely processed paraffin embedded bone marrow sections. Bone marrow biopsies and clot sections were stained with rabbit antihuman erythrocyte spectrin antibodies, specific for erythroid cells
Marian A Rollins-Raval et al.
American journal of clinical pathology, 137(1), 30-38 (2011-12-20)
Neoplastic erythroid proliferations may represent a diagnostic challenge owing to the difficulty in characterizing immature erythroblasts. Immunohistochemical expression of aldehyde dehydrogenase (ALDH), carbonic anhydrase isoenzyme I (CA I), and CD2-associated protein (CD2AP) was assessed in 66 bone marrow biopsy specimens
Henry Y Dong et al.
The American journal of surgical pathology, 35(5), 723-732 (2011-03-19)
Histology assessment of erythroid precursors in bone marrow biopsies can be challenging under pathologic conditions and often requires ancillary studies. CD71 (transferring receptor-1) is known to be expressed in the earliest erythroid precursors, and has been useful for flow cytometry.
C C Chang et al.
American journal of clinical pathology, 114(5), 807-811 (2000-11-09)
The present study was designed to evaluate the lineage differentiation (particularly monocytic differentiation) of immature myeloid cells in granulocytic sarcoma (GS) by immunohistochemistry and correlate the results with lineage differentiation of blasts in the bone marrow and to determine the

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