P1386

Propionic acid

≥99.5%

• Synonym(s): Acid C₃, Propanoic acid, Propanyl acid
• Linear Formula: CH₃CH₂COOH
• CAS Number: 79-09-4
• Molecular Weight: 74.08
• Beilstein/REAXYS Number: 506071
• EC Number: 201-176-3
• MDL number: MFCD00002756
• UNSPSC Code: 12352106
• eCl@ss: 39021305
• PubChem Substance ID: 329820094
• NACRES: NA.21

Properties

• vapor density: 2.55 (vs air)
• Quality Level: 200
• vapor pressure: 2.4 mmHg ( 20 °C)
• assay: ≥99.5%
• autoignition temp.: 955 °F
• expl. lim.: 12.1 %
• impurities: ≤0.25% water (Karl Fischer)
• color: ≤10, APHA:
• refractive index: n20/D 1.386 (lit.)
• bp: 141 °C (lit.)
• mp: −24-−23 °C (lit.)
• density: 0.993 g/mL at 25 °C (lit.)
• SMILES string: CCC(O)=O
• InChI: 1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
• InChI key: XBDQKXXYIPTUBI-UHFFFAOYSA-N

Description

General description

Propionic acid (PA) is a naturally occurring carboxylic acid, which in its pure state exists as a colorless corrosive liquid with an unpleasant odor. It is miscible in water. Industrially it is produced by hydrocarboxylation of ethylene in presence nickel carbonyl as a catalyst. PA has been found to reduce food intake, lower the fatty acids content in plasma and liver, might improve tissue insulin sensitivity and exerts immunosuppressive actions. Propionic acid is an excellent raw material as it is stable, cheap and safe and can even be used as a food additive.

Application

• Distribution Characteristics of Low-Molecular-Weight Organic Acids in Reclaimed Soil Filled with Fly Ash: A Study.: This research investigates the presence and distribution of propionic acid among other organic acids in reclaimed soils treated with fly ash. The study provides insights into the environmental impact and potential remediation strategies for soils contaminated with industrial by-products (Zheng et al., 2024).


• Effects of Black Soldier Fly (Hermetia illucens L., BSF) Larvae Addition on In Vitro Fermentation Parameters of Goat Diets.: This study examines how the addition of black soldier fly larvae affects the fermentation process of goat diets, including the production of propionic acid. The findings suggest potential benefits for improving animal nutrition and gut health (Lu et al., 2024).


• NMR Spectroscopy in Diagnosis and Monitoring of Methylmalonic and Propionic Acidemias.: This review highlights the use of NMR spectroscopy to diagnose and monitor methylmalonic and propionic acidemias, providing a non-invasive method for tracking these metabolic disorders. The study underscores the clinical significance of propionic acid in metabolic research (Deleanu & Nicolescu, 2024).


• The New Buffer Salt-Protected Sodium Butyrate Promotes Growth Performance by Improving Intestinal Histomorphology, Barrier Function, Antioxidative Capacity, and Microbiota Community of Broilers.: This study explores how propionic acid, along with sodium butyrate, improves the growth performance and gut health of broilers. The research demonstrates the beneficial effects of these acids on poultry farming (Melaku et al., 2024).


• Prevotella enterotype associates with diets supporting acidic faecal pH and production of propionic acid by microbiota.: This study links the presence of the Prevotella enterotype in the gut microbiota to diets that promote the production of propionic acid, emphasizing the role of diet in modulating gut health and metabolic functions (Adamberg & Adamberg, 2024).

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H226,H314,H335
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 129.2 °F - closed cup
• flash_point_c: 54 °C - closed cup