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Key Documents

917133

Sigma-Aldrich

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

≥95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C12H20Cl2N2
CAS Number:
Molecular Weight:
263.21
MDL number:
UNSPSC Code:
12352116

Quality Level

assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

amine

storage temp.

2-8°C

SMILES string

NCC1=CC=C(C=C1)C2CCNCC2.Cl.Cl

Application

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable


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