27301

Salicylic acid

meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance)

• Synonym(s): 2-Hydroxybenzoic acid
• Linear Formula: 2^-(HO)C₆H₄CO₂H
• CAS Number: 69-72-7
• Molecular Weight: 138.12
• Beilstein/REAXYS Number: 774890
• EC Number: 200-712-3
• MDL number: MFCD00002439
• UNSPSC Code: 12352100
• PubChem Substance ID: 24856524
• NACRES: NA.21

Properties

• vapor density: 4.8 (vs air)
• Quality Level: 200
• vapor pressure: 1 mmHg ( 114 °C)
• assay: 99.5-100.5% (calc. to the dried substance)
• quality: meets analytical specification of Ph. Eur., BP, USP
• impurities: residual solvents, complies; ≤0.001% heavy metals (as Pb); ≤0.2% related subst. (HPLC)
• ign. residue: ≤0.05% (as SO₄)
• loss: ≤0.3% loss on drying
• bp: 211 °C (lit.)
• mp: 158-161 °C (lit.); 158-161 °C
• anion traces: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤200 mg/kg
• suitability: complies for appearance of solution; complies for identity
• application(s): pharmaceutical (small molecule)
• functional group: carboxylic acid
• SMILES string: OC(=O)c1ccccc1O
• InChI: 1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
• InChI key: YGSDEFSMJLZEOE-UHFFFAOYSA-N
• Gene Information: human ... ALB(213) , PTPN1(5770)

Description

Application

• Salinity stress management in agriculture: A study demonstrated the application of salicylic acid in ameliorating salinity stress in barley, revealing its potential to enhance crop resilience to saline environments, thereby contributing to sustainable agricultural practices (Hanif et al., 2024).
• Enhanced pharmaceutical gel performance: Research on nitrocellulose for prolonged permeation of Levofloxacin HCl-Salicylic Acid In Situ gel emphasized its utility in enhancing drug delivery systems, particularly in treating bacterial infections with improved efficacy (Khaing et al., 2024).
• Biotechnological production of withanolides: Salicylic acid was applied as an elicitor in the hairy root culture of Withania somnifera, significantly boosting the production of withanolides and phenolic acids, vital for pharmaceutical applications due to their therapeutic properties (Halder and Ghosh, 2024).

Safety Information

• pictograms: GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H302,H318,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 314.6 °F - closed cup
• flash_point_c: 157 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves