21186

Calcium ionophore III

Selectophore^™, function tested

• Synonym(s): Calcium Ionophore A23187, Antibiotic A 23187, Calimycin
• Empirical Formula (Hill Notation): C₂₉H₃₇N₃O₆
• CAS Number: 52665-69-7
• Molecular Weight: 523.62
• Beilstein/REAXYS Number: 1096801
• EC Number: 258-084-1
• MDL number: MFCD00151202
• UNSPSC Code: 26111700
• PubChem Substance ID: 329752113
• NACRES: NB.61

Properties

• grade: for ion-selective electrodes
• Quality Level: 200
• product line: Selectophore^™
• form: solid
• quality: function tested
• antibiotic activity spectrum: Gram-positive bacteria; fungi
• mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• InChI key: HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Description

General description

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

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Application

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves