114189

Acetyl chloride

reagent grade, 98%

• Synonym(s): Acetic acid chloride, Acetic chloride, Ethanoyl chloride
• Linear Formula: CH₃COCl
• CAS Number: 75-36-5
• Molecular Weight: 78.50
• Beilstein/REAXYS Number: 605303
• EC Number: 200-865-6
• MDL number: MFCD00000719
• UNSPSC Code: 12352100
• eCl@ss: 39050501
• PubChem Substance ID: 24847160
• NACRES: NA.21

Properties

• grade: reagent grade
• Quality Level: 200
• vapor density: 2.7 (vs air)
• vapor pressure: 11.69 psi ( 20 °C); 32.33 psi ( 55 °C)
• assay: 98%
• form: liquid
• autoignition temp.: 1353 °F
• expl. lim.: 19 %
• refractive index: n20/D 1.389 (lit.)
• bp: 52 °C (lit.)
• mp: −112 °C (lit.)
• density: 1.104 g/mL at 25 °C (lit.)
• functional group: acyl chloride
• SMILES string: CC(Cl)=O
• InChI: 1S/C2H3ClO/c1-2(3)4/h1H3
• InChI key: WETWJCDKMRHUPV-UHFFFAOYSA-N

Description

General description

Acetyl chloride is used as an acylating reagent for electrophilic acetylation of alkynes, alkenes, arenes, saturated alkanes, enolates, and organometallics.

Acetyl chloride is a colorless acyl halide. On reaction with ammonia and alcohols, it affords acetamide and esters of acetic acid, respectively. Structural parameters and rotational constants of its isotopic forms have been evaluated from the microwave spectral investigations.

Application

Acetyl chloride has been used in the Lepage and Roy fatty acids analysis, and robotic fatty acid analysis. It may be used for the qualitative in situ synthesis of hydrogen chloride.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H225,H314
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 41.0 °F - closed cup
• flash_point_c: 5 °C - closed cup