ABT406

Anti-LRRFIP1 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Leucine-rich repeat flightless-interacting protein 1, LRR FLII-interacting protein 1, GC-binding factor 2, TAR RNA-interacting protein
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human
• technique(s): western blot: suitable
• UniProt accession no.: Q32MZ4
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... LRRFIP1(9208)

Description

General description

Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1), also known as GC-binding factor 2 or TAR RNA-interacting protein, and encoded by the gene name LRRFIP1 or GCF2 or TRIP, is a transcriptional repressor that mainly plays a cytoskeletal role. LRRFIP1 is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a β-catenindependent pathway.

Immunogen

KLH-conjugated synthetic peptide corresponding to human LRRFIP1.

Application

Anti-LRRFIP1 Antibody detects level of LRRFIP1 & has been published & validated for use in LRRFIP1.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Quality

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected LRRFIP1 in human colon tissue lysate.

Target description

~85 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 4 isoforms produced by alternative splicing ranging between ~73 kDa and ~89 kDa

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable