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Key Documents

ABE480

Sigma-Aldrich

Anti-Centrin-2 Antibody

serum, from rabbit

Synonym(s):

Centrin-2, Caltractin isoform 1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_004335

UniProt accession no.

P41208

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CETN2(1069)

General description

Centrin-2 is also called Caltractin isoform 1. Centrin-2 is involved in microtubule organization, structure and function, and is required for centriole duplication and spindle formation. Centrin-2 also has a role in regulating cytokinesis, genome stability and global genome nucleotide excision repair (GG-NER) as component of the XPC complex.

Immunogen

Recombinant protein corresponding to human Centrin-2.

Application

Anti-Centrin-2 Antibody is a highly specific rabbit polyclonal antibody, that targets Centrin & has been tested in western blotting, ICC, IHC & IP.
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Centrin-2 in MDCK cells (Koch, A., et al. (2010). Mol Biol Cell. 21(2):219-231.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Centrin-2 in wild type and galectin-3 null mouse kidney tissues (Koch, A., et al. (2010). Mol Biol Cell. 21(2):219-231.).

Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Centrin-2 in MDCK cell lysate (Koch, A., et al. (2010). Mol Biol Cell. 21(2):219-231.).

Quality

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Centrin-2 in 10 µg of Jurkat cell lysate.

Target description

~18 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Annett Koch et al.
Molecular biology of the cell, 21(2), 219-231 (2009-11-20)
Galectin-3 is a beta-galactoside-binding protein widely expressed in all epithelia where it is involved in tissue homeostasis and cancer progression. We recently reported unique abnormalities in the identity of membrane domains in galectin-3 null mutant mice, suggesting that galectin-3 may
Juliette Azimzadeh et al.
The Journal of cell biology, 185(1), 101-114 (2009-04-08)
Centrin has been shown to be involved in centrosome biogenesis in a variety of eukaryotes. In this study, we characterize hPOC5, a conserved centrin-binding protein that contains Sfi1p-like repeats. hPOC5 is localized, like centrin, in the distal portion of human
Renee A Lopez et al.
Bio-protocol, 7(21), e2599-e2599 (2017-11-05)
Male gametes (spermatozoids) are the only motile cells produced during the life cycle of land plants. While absent from flowering and most cone-bearing plants, motile cells are found in less derived taxa, including bryophytes (mosses, liverworts and hornworts), pteridophytes (lycophytes

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