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Key Documents

AB5122

Sigma-Aldrich

Anti-Adrenergic Receptor Antibody, β 3

Chemicon®, from rabbit

Synonym(s):

Anti-Anti-B3AR, Anti-Anti-GPCR

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_000025.1

UniProt accession no.

P13945

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ADRB3(155)

Specificity

Human beta 3 adrenergic receptor (B3AR) is a member of the G-protein coupled receptor superfamily. They typically contain 7 transmembrane domains (Barak et al., 1995) Human B3AR is 408 aa membrane protein (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993).

Immunogen

A 19 aa sequence at the C-terminus of the human B3AR, splce variant 3 (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993). Control peptide is available under catalog number AG388.

Application

Anti-Adrenergic Receptor Antibody, β 3 detects level of Adrenergic Receptor & has been published & validated for use in ELISA, IH & WB.
Western blot: 1-10 μg/mL using Chemiluminescence technique

ELISA: 1:10,000 - 100,000

Immunohistochemistry: 2-20 μg in formaldehyde fixed tissue.

Optimal working dilutions must be determined by end user.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J G Granneman et al.
Molecular pharmacology, 42(6), 964-970 (1992-12-01)
DNA blot analysis of the cloned rat beta 3-adrenergic receptor gene revealed unexpected restriction enzyme cleavage sites that suggested the presence of one or more introns near the end of the coding block. This region of the rat gene was
Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia.
Rouget, C; Barthez, O; Goirand, F; Leroy, MJ; Breuiller-Fouche, M; Rakotoniaina et al.
Biology of reproduction null
{beta}1, {beta}2, {beta}3-Adrenoceptors and NHERF1 Expression in Human Bronchi and Their Modifications in Cystic Fibrosis.
Bossard F, Silantieff E, Lavazais-Blancou E, Robay A, Sagan C, Rozec B, Gauthier C
American Journal of Respiratory Cell and Molecular Biology null
J M Lelias et al.
FEBS letters, 324(2), 127-130 (1993-06-14)
We report the molecular cloning of a beta 3-adrenergic receptor [beta 3-AR] cDNA from human brown adipose tissue. The cDNA-encoded protein is identical to the previously cloned beta 3-AR but with 6 additional amino acids at the C-terminus. The C-terminus
The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.
Barak, L S, et al.
Biochemistry, 34, 15407-15414 (1995)
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