8.51008
TBTU
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®
Synonym(s):
TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate
About This Item
Quality Level
product line
Novabiochem®
assay
≥98.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
195-199 °C (decomposes)
application(s)
peptide synthesis
storage temp.
15-25°C
InChI
1S/C11H16N5O.B.4FH/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;;;;;/h5-8H,1-4H3;;4*1H/q+1;+3;;;;/p-4
InChI key
SHGLJDNRZIDILW-UHFFFAOYSA-J
Related Categories
General description
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.
Application
- Synthesis of phospho-urodilatin by combination of global phosphorylation with the segment coupling approach.: This research focuses on the synthesis of phospho-urodilatin, demonstrating the effectiveness of TBTU as a coupling reagent in segment coupling strategies for peptide synthesis (Mostafavi et al., 1996).
- Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.: The study investigates the impact of tertiary amines on carbodiimide-mediated peptide synthesis, highlighting the role of TBTU in enhancing peptide coupling efficiency (Beyermann et al., 1991).
Linkage
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %
Legal Information
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 1 - Skin Sens. 1A
Storage Class
4.1A - Other explosive hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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