662056
Ubiquitin Aldehyde
Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover.
Synonym(s):
ubiquitin hydrolase inhibitor
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About This Item
UNSPSC Code:
12352200
Recommended Products
Quality Level
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
DMSO: 50 mg/mL
aqueous buffer: soluble
shipped in
ambient
storage temp.
−20°C
General description
Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease rates of ubiquitin-dependent degradation.
Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease the rates of ubiquitin-dependent degradation.
Biochem/physiol Actions
Cell permeable: no
Primary Target
multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover
multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover
Product does not compete with ATP.
Reversible: no
Shown to inhibit the activity of Isopeptidase T (Cat. No. 419700) and Ubiquitin C-Terminal Hydrolase (Cat. No. 662090)
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 150 mM HCL.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C).
Other Notes
Melandri, F., et al. 1996. Biochemistry 35, 12893.
Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.
Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Mengmeng Niu et al.
PLoS biology, 19(2), e3001113-e3001113 (2021-02-25)
Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program
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