573098

JAK2 Inhibitor III, SD-1029

The JAK2 Inhibitor III, SD-1029, also referenced under CAS 118372-34-2, controls the biological activity of JAK2.

• Synonym(s): JAK2 Inhibitor III, SD-1029, 9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488
• Empirical Formula (Hill Notation): C₂₅H₃₀Cl₂N₂O₃ · 2HBr
• CAS Number: 118372-34-2
• Molecular Weight: 639.25
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥80% (sum of isomers, HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: off-white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µM. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Duan, Z., et al. 2006. Clin. Cancer Res.12, 6844.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable