5.05145

(+)-Tubocurarine Chloride

• Synonym(s): (+)-Tubocurarine Chloride, Nicotinic Acetylcholine Receptor Antagonist, (+)-Tubocurarine chloride, D-tubocurarine, DTC
• Empirical Formula (Hill Notation): C₃₇H₄₂Cl₂N₂O₆
• CAS Number: 57-94-3
• Molecular Weight: 681.65
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: H₂O: soluble
• storage temp.: −20°C
• InChI: 1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1
• InChI key: GXFZCDMWGMFGFL-KKXMJGKMSA-N

Description

General description

A potent competitive antagonist of nAChR (IC50= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

A potent competitive antagonist of nAChR (IC₅₀ = 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

Biochem/physiol Actions

Primary Target
nAch

Warning

Toxicity: Toxic (F)

Preparation Note

Warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bowman, C., 2006. Br. J. Pharmacol.147, S277.
Wenningmann, I., et al. 2001. Mol. Pharmacol.60, 790.
Pederson, X., 1990. Proc. Natl. Acad. Sci. USA.87, 2785.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable