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M-039

Supelco

Meprobamate solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C9H18N2O4
CAS Number:
57-53-4
Molecular Weight:
218.25
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

CCCC(C)(COC(N)=O)COC(N)=O

InChI

1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)

InChI key

NPPQSCRMBWNHMW-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

General description

Meprobamate is marketed as an anti-anxiety drug and muscle relaxant under the trade names Milltown, Meprospan, and Equanil. This Certified Spiking Solution® is suitable for GC/MS or LC/MS testing applications in forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.

Application


  • Meprobamate solution for neurotransmitter research: Meprobamate is investigated for its impact on the uptake and translocation of pharmaceutical compounds by vegetables, providing insights into environmental interactions and bioaccumulation potential. This research is valuable for understanding how sedative compounds like meprobamate interact with biological systems beyond their primary pharmacological targets (Wu et al., 2013).

  • High-purity meprobamate for in vitro studies: The CNS activities of various plant extracts, including their interaction with CNS depressants like meprobamate, are studied to assess potential synergistic effects and therapeutic applications. Such research is crucial for pharmaceutical and neurological studies, providing a basis for developing new therapeutic strategies (Pal and Samanta, 2011).

  • Meprobamate as an anxiolytic agent in pharmacological research: Investigations into the CNS depressant activities of different plant roots highlight the importance of meprobamate as a comparative standard in pharmacological research. These studies are essential for validating the efficacy and safety of new anxiolytic candidates (Pal et al., 2011).

  • Meprobamate solution for GABA receptor assay: The evaluation of CNS activities of various natural extracts in comparison with known CNS depressants like meprobamate offers valuable data on their mechanisms of action, particularly concerning GABAergic activity. This research supports the use of meprobamate as a benchmark in neuropharmacological assays (Pal et al., 2009).

  • Meprobamate research compound for biochemistry labs: Studies on the CNS effects of botanical extracts using meprobamate as a reference drug help delineate the pathways involved in CNS depression and provide a pharmacological basis for the use of these plants in traditional medicine. This kind of research underpins the development of novel anxiolytic drugs derived from natural sources (Pal, 2008).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Arun Kumar et al.
Regulatory toxicology and pharmacology : RTP, 57(2-3), 146-156 (2010-02-16)
This study presents a step-wise development of a quantitative pharmaceutical risk assessment (QPhRA, hereafter) framework, including Monte Carlo uncertainty analysis for meprobamate, carbamazepine, and phenytoin during (1) accidental exposures of stream water and fish consumption and (2) direct ingestion of
Iain M McIntyre et al.
Journal of analytical toxicology, 36(3), 177-181 (2012-03-16)
Carisoprodol is a therapeutic and occasionally abused centrally acting muscle relaxant. We compare central blood and liver concentrations of carisoprodol and the metabolite meprobamate to concentrations in peripheral blood in 11 medical examiner cases. Specimens were initially screened for alcohol
Marina Del Fiacco et al.
Journal of neurology, neurosurgery, and psychiatry, 86(4), 393-397 (2014-10-08)
The transient receptor potential vanilloid type-1 receptor (TRPV1) and the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) appear to be differently involved in migraine pain. A role of neurovascular scalp structures is also suggested by several data. We
Bonnie V Laws et al.
The Science of the total environment, 409(6), 1087-1094 (2011-01-08)
The attenuation of a diverse suite of contaminants of emerging concern (CECs) and bulk water quality changes was evaluated at a surface-spreading aquifer recharge operation across a detailed subsurface profile (9 locations), representing both short- and long-travel times (10 h
Marie Orre et al.
Neurobiology of aging, 35(12), 2746-2760 (2014-07-09)
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype. To get an insight into the molecular changes underlying AD induced astrocyte and microglia
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