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860655P

Avanti

sphinganine-1-phosphate (d17:0)

Avanti Research™ - A Croda Brand 860655P, powder

Synonym(s):

D-erythro-sphinganine-1-phosphate (C17 base)

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About This Item

Empirical Formula (Hill Notation):
C17H38NO5P
CAS Number:
474923-29-0
Molecular Weight:
367.46
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860655P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860655P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](CCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O

InChI

1S/C17H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(19)16(18)15-23-24(20,21)22/h16-17,19H,2-15,18H2,1H3,(H2,20,21,22)/t16-,17+/m0/s1

InChI key

RTCZJPCPBSBOKB-DLBZAZTESA-N

Application

Sphinganine-1-phosphate (d17:0) has been used as an internal standard in mass spectroscopy for quantification of shingolipids.

Biochem/physiol Actions

Exogenous sphinganine 1-phosphate activates sphingosine-1-phosphate receptor 1 (S1P1) and exhibits protective effects against hepatic and renal ischemia and reperfusion (IR).

Packaging

5 mL Amber Glass Screw Cap Vial (860655P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

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Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P 1 receptor activation
Park SW, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 90(8), 1209-1209 (2010)
TP53 is required for BECN1-and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition
Lim S, et al.
Autophagy, 14(6), 942-957 (2018)
Ladan Dawoody Nejad et al.
Scientific reports, 10(1), 8268-8268 (2020-05-20)
Sphingosine-1-phosphate is a signaling molecule involved in the control of cell migration, differentiation, survival and other physiological processes. This sphingolipid metabolite can be degraded by the action of sphingosine-1-phosphate lyase (SPL) to form hexadecenal and ethanolamine phosphate. The importance of

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