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Key Documents

QBD11135

Sigma-Aldrich

Phthalimidooxy-dPEG®12-NHS ester

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About This Item

Empirical Formula (Hill Notation):
C39H60N2O19
Molecular Weight:
860.90
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22

assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCON1C(C2=C(C1=O)C=CC=C2)=O)ON3C(CCC3=O)=O

Features and Benefits

Phthalimidooxy-dPEG®12-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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