934429

3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

≥95%

• Synonym(s): 3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₁N₃O₂ · xHCl
• Molecular Weight: 287.36 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder
• storage temp.: 2-8°C
• SMILES string: O=C1NC(C(NC2=CC=C(C=C2)C3CCNCC3)CC1)=O.[xHCl]

Description

Application

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable