924229

(S,R,S)-AHPC-Me

95%

• Synonym(s): (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide, PROTAC^® research ligand, VH032 methyl derivative
• Empirical Formula (Hill Notation): C₂₃H₃₂N₄O₃S
• CAS Number: 1948273-02-6
• Molecular Weight: 444.59
• MDL number: MFCD31630815
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• ligand: VH032
• Quality Level: 100
• assay: 95%
• form: powder
• storage temp.: 2-8°C
• SMILES string: C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Description

Application

(S,R,S)-AHPC-Me is a VH032 derivative used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This was previously listed under ATEH961B8E6E.

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Targeted protein degradation

Other Notes

Discovery of ERD-308 as a highly potent proteolysis targeting chimera (PROTAC) degrader of estrogen receptor (ER)

Discovery of ARD-69 as a highly potent proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) for the treatment of prostate cancer

Design, Synthesis, and Biological Evaluation of MEK PROTACs

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable