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903981

Sigma-Aldrich

2,3,7,8-Tetrafluorothianthrene-S-oxide

≥95%

Synonym(s):

2,3,7,8-Tetrafluorothianthrene-5-oxide, Fluorinated sulfoxide-based thianthrene reagent, Ritter C-H functionalization linchpin, TFT S-oxide, TFT-reagent

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About This Item

Empirical Formula (Hill Notation):
C12H4F4OS2
CAS Number:
Molecular Weight:
304.28
UNSPSC Code:
12352101
NACRES:
NA.22

assay

≥95%

form

solid

mp

253 °C

functional group

fluoro
sulfoxide
thioether

storage temp.

−20°C

Application

2,3,7,8-Tetrafluorothianthrene-S-oxide (TFT S-oxide) is a fluorinated sulfoxide-based thianthrene reagent for late-stage C-H functionalization. Developed by the Ritter Lab, C-H functionalization by thianthrenation with TFT S-oxide proceeds with >99% selectivity and furnishes functionalized arenes serving as synthetic linchpins for further participation in diverse transformations.
The nonfluorinated thianthrene S-oxide is also available as catalog# 903973 for all arenes more electron-rich than anisole.

Legal Information

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

Related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Florian Berger et al.
Nature, 567(7747), 223-228 (2019-03-15)
Direct C-H functionalization can quickly increase useful structural and functional molecular complexity1-3. Site selectivity can sometimes be achieved through appropriate directing groups or substitution patterns1-4-in the absence of such functionality, most aromatic C-H functionalization reactions provide more than one product

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