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902691

Sigma-Aldrich

Hydroxy-PEG5-t-butyl ester

Synonym(s):

tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu

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About This Item

Empirical Formula (Hill Notation):
C17H34O8
CAS Number:
Molecular Weight:
366.45
MDL number:
UNSPSC Code:
51171641

assay

≥95%

form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.448

density

1.071

functional group

ester
hydroxyl

storage temp.

−20°C

SMILES string

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Related product

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jordan H Wosnick et al.
Journal of the American Chemical Society, 127(10), 3400-3405 (2005-03-10)
A set of carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) has been synthesized in which the carboxylic acid groups are separated from the polymer backbone by oligo(ethylene glycol) spacer units. These polymers are soluble in water and organic solvents and have photophysical properties

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