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636010

Sigma-Aldrich

3,5-Dimethylpyrazole-4-boronic acid pinacol ester

97%

Synonym(s):

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)-1H-pyrazole, 3,5-Dimethyl-4-pyrazoleboronic acid pinacol ester

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About This Item

Empirical Formula (Hill Notation):
C11H19BN2O2
CAS Number:
857530-80-4
Molecular Weight:
222.09
MDL number:
MFCD05663852
UNSPSC Code:
12352103
PubChem Substance ID:
24882751
NACRES:
NA.22

Quality Level

100

assay

97%

form

solid

mp

163-168 °C (lit.)

SMILES string

Cc1n[nH]c(C)c1B2OC(C)(C)C(C)(C)O2

InChI

1S/C11H19BN2O2/c1-7-9(8(2)14-13-7)12-15-10(3,4)11(5,6)16-12/h1-6H3,(H,13,14)

InChI key

GNUDAJTUCJEBEI-UHFFFAOYSA-N

Related Categories

Application

3,5-Dimethylpyrazole-4-boronic acid pinacol ester can be used:
  • To synthesize 9H-pyrimido[4,5-b]indole and aryl-benzimidazole based BET bromodomain and extra terminal (BET) protein inhibitors.
  • To prepare naphthalimide based photo-exchangeable photochromic fluorescent molecules.
  • As a reactant to develop DNA-encoded chemical libraries by palladium-catalyzed Suzuki coupling reaction with DNA-linked aryl halides.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP6892
MKBL8903V
MKBF8779V
47698PJ
05707BJ

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Structure-guided discovery of a novel, potent, and orally bioavailable 3, 5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Sperandio D, et al.
Bioorganic & Medicinal Chemistry, 27(3), 457-469 (2019)
Development of DNA-compatible suzuki-miyaura reaction in aqueous media
Li J and Huang H
Bioconjugate Chemistry, 29(11), 3841-3846 (2018)

Articles

Suzuki–Miyaura Coupling Reagents

This brochure contains a comprehensive selection of boronic acids, boronic acid esters, diboron esters, and transition-metal catalysts useful for the Suzuki–Miyaura coupling reaction

Boronic Acid Esters

The synthesis of biaryl compounds via the Suzuki–Miyaura coupling reaction has become more commonplace now that many arylboronic acids are readily available.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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