268119

Diethyl methylphosphonate

97%

• Synonym(s): Bis(diethoxyphosphinyl)methane, DEMP, Diethoxymethylphosphine oxide
• Linear Formula: CH₃P(O)(OC₂H₅)₂
• CAS Number: 683-08-9
• Molecular Weight: 152.13
• Beilstein/REAXYS Number: 1753416
• EC Number: 211-667-4
• MDL number: MFCD00009813
• UNSPSC Code: 12352108
• PubChem Substance ID: 24856263
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.414 (lit.)
• bp: 194 °C (lit.)
• density: 1.041 g/mL at 25 °C (lit.)
• functional group: phosphonate
• SMILES string: CCOP(C)(=O)OCC
• InChI: 1S/C5H13O3P/c1-4-7-9(3,6)8-5-2/h4-5H2,1-3H3
• InChI key: NYYLZXREFNYPKB-UHFFFAOYSA-N

Description

Application

Reactant for the synthesis of:

• Fluoroalkyl α- and β-aminophosphonates
• Acyclic nucleoside phosphonates with branched phosphonoethoxy-Et chains as potential antivirals
• Difluoromethyl arylphosphonates
• Pyridone alkaloids with neuritogenic activity
• Lipophilic meropenem-derived prodrugs
• Phomactin cyclohexane core and diterpenoid framework
• Phosphonylated peptides via solid-phase synthesis

Reagent employed in the synthesis of α-alkenyl, γ-hydroxyl, and dialkyl fluoroalkynyl phosphonates.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 167.0 °F - closed cup
• flash_point_c: 75 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter