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Sigma-Aldrich

Quinazoline

99%

Synonym(s):

1,3-Benzodiazine, Benzopyrimidine

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About This Item

Empirical Formula (Hill Notation):
C8H6N2
CAS Number:
253-82-7
Molecular Weight:
130.15
Beilstein/REAXYS Number:
109370
EC Number:
205-965-3
MDL number:
MFCD00006712
UNSPSC Code:
12352100
PubChem Substance ID:
24847559
NACRES:
NA.22

assay

99%

form

solid

bp

243 °C (lit.)

mp

46-48 °C (lit.)

solubility

H2O: freely soluble
organic solvents: soluble

SMILES string

c1ccc2ncncc2c1

InChI

1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H

InChI key

JWVCLYRUEFBMGU-UHFFFAOYSA-N

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General description

Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.

Application

Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.

Biochem/physiol Actions

Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

222.8 °F - closed cup

flash_point_c

106 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhijiang Fan et al.
Molecular diversity, 22(3), 657-667 (2018-03-27)
A series of structurally novel 3-thioether-1-(quinazolin-4-yl)-1H-1,2,4-triazol-5-amine derivatives (7a-7r) were designed and synthesized based on a pharmacophore hybrid approach, and screened for their antibacterial and antifungal activities in vitro. All the target compounds were fully characterized through [Formula: see text]H NMR
Elham Bagheri et al.
Current pharmaceutical design, 24(13), 1395-1404 (2018-02-01)
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell
Siva Jyothi Buggana et al.
Computational biology and chemistry, 79, 110-118 (2019-02-21)
Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway. In this study, a series
Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.
Hladikova J, et al.
Sensing in Electroanalysis, 3, 165-175 (2008)
Reddy Amala et al.
BioImpacts : BI, 11(1), 15-22 (2021-01-21)
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue. A signaling cascade of growth factors and
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