- Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.
Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.
Journal of pharmaceutical and biomedical analysis (2017-01-17)
Lucie Zelena, Josef Reznicek, Martina Ceckova, Hana Sklenarova
PMID28092857
ABSTRAKT
Efavirenz is an antiretroviral drug used in the treatment of HIV-positive patients. A simple, fast and sensitive high-performance liquid chromatography (HPLC) method was developed in order to determine efavirenz in three types of samples provided from pharmacokinetic studies. The analysis took 5min and was performed using a C18 analytical column (Discovery HS C18, 150×4.6mm, particle size of 5μm) in isocratic mode with a mobile phase containing acetonitrile and water (65:35, v/v), a flow rate of 1.6mLmin
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