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1096622

USP

Carvedilol

United States Pharmacopeia (USP) Reference Standard

Synonim(y):

1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190

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About This Item

Wzór empiryczny (zapis Hilla):
C24H26N2O4
Numer CAS:
72956-09-3
Masa cząsteczkowa:
406.47
Numer MDL:
MFCD00864692
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329749239
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

rodzina API

carvedilol

producent / nazwa handlowa

USP

Zastosowanie

pharmaceutical (small molecule)

format

neat

ciąg SMILES

OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

Klucz InChI

OGHNVEJMJSYVRP-UHFFFAOYSA-N

informacje o genach

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Carvedilol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Carvedilol Tablets

Działania biochem./fizjol.

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

Sales restrictions may apply.
This page may contain text that has been machine translated.

produkt powiązany

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Cennik

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Carvedilol, European Pharmacopoeia (EP) Reference Standard

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Carvedilol for system suitability, European Pharmacopoeia (EP) Reference Standard

1096644

Carvedilol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1096677

Carvedilol Related Compound E, United States Pharmacopeia (USP) Reference Standard

1096633

Carvedilol Related Compound A, United States Pharmacopeia (USP) Reference Standard

1096666

Carvedilol Related Compound D, United States Pharmacopeia (USP) Reference Standard

1096655

Carvedilol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1096688

Carvedilol System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

PHR2434

Carvedilol Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2435

Carvedilol Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2952

Carvedilol Related Compound B, pharmaceutical secondary standard, certified reference material

PHR2953

Carvedilol Related Compound C, pharmaceutical secondary standard, certified reference material

Piktogramy

Health hazardEnvironment
GHS08,GHS09

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H373,H411

Zwroty wskazujące środki ostrożności

P260 - P273 - P314 - P391 - P501

Klasyfikacja zagrożeń

Aquatic Chronic 2 - STOT RE 2

Organy docelowe

Liver,spleen,Uterus (including cervix),Adrenal gland

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Péter Ferdinandy et al.
Pharmacological reviews, 66(4), 1142-1174 (2014-09-28)
Pre-, post-, and remote conditioning of the myocardium are well described adaptive responses that markedly enhance the ability of the heart to withstand a prolonged ischemia/reperfusion insult and provide therapeutic paradigms for cardioprotection. Nevertheless, more than 25 years after the
George L Bakris et al.
Reviews in cardiovascular medicine, 9(2), 96-105 (2008-07-29)
Few patients with hypertension meet recommended target blood pressure goals, and most hypertensive patients require at least 2 antihypertensive medications from different pharmacologic classes to adequately lower blood pressure. beta-Blockers are guideline-recommended for the treatment of hypertension with compelling indications.
Timothy Self et al.
The American journal of the medical sciences, 342(1), 56-61 (2011-02-05)
Cocaine-induced myocardial infarction (MI) is well documented. Current literature recommends avoiding beta-blockers in the acute care setting, but after discharge from the hospital, benefits of beta-blocker use may outweigh risks in patients with recent MI resulting from cocaine use. Cardioselective
Subhashis Chakraborty et al.
Expert opinion on drug metabolism & toxicology, 6(2), 237-250 (2010-01-16)
Carvedilol, a non-selective beta-blocker, has recently drawn attention because of its therapeutic benefits over other prescribed analogues for the treatment of cardiovascular diseases (CVDs). The present review attempts to present the clinical efficacy of carvedilol in comparison to other available
Adrian J Stanley et al.
Journal of hepatology, 61(5), 1014-1019 (2014-06-24)
Rebleeding after an initial oesophageal variceal haemorrhage remains a significant problem despite therapy with band ligation, non-selective β-blockers or a combination of these. Carvedilol is a vasodilating non-selective β-blocker with alpha-1 receptor and calcium channel antagonism. A recent study has
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