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Key Documents
U9507
Urocortin II mouse
Synonim(y):
UCN-II
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
Próba
≥97% (HPLC)
Postać
solid
metody
immunohistochemistry: suitable
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
mouse ... Ucn2(171530)
Amino Acid Sequence
Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2
Zastosowanie
Mouse urocortin II can be used for immunohistochemistry.
Działania biochem./fizjol.
Urocortin II is a CRF-related neuropeptide having high affinity for CRF2 receptor. It stimulates protein kinase A through CRF2 receptor and increases the contractility in rabbit ventricular myocytes. It also facilitates pro-inflammatory effects in human intestinal cells through corticotropin-releasing hormone receptor 2α.
corticotropin-releasing factor (CRF) peptide
Inne uwagi
Lyophilized from 0.1% TFA in H2O
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Li-Zhen Yang et al.
Cardiovascular research, 69(2), 402-411 (2006-01-03)
Urocortin II (UcnII), a peptide of the corticotropin-releasing factor (CRF) family, exerts profound actions on the cardiovascular system. Direct effects of UcnII on adult cardiomyocytes have not been evaluated before. Our aim was to characterize functional effects of UcnII on
Alan C Moss et al.
Gut, 56(9), 1210-1217 (2007-04-07)
Urocortin II (UcnII) is a neuropeptide that binds with high affinity to the corticotropin-releasing hormone receptor 2 (CRHR2) in peripheral tissues. UcnII is synthesised in the intestine, but its role in human intestinal inflammation is largely unknown. Responses of human
Dimitri Tränkner et al.
Cell reports, 29(4), 791-799 (2019-10-24)
Aberrant microglia activity is associated with many neurological and psychiatric disorders, yet our knowledge about the pathological mechanisms is incomplete. Here, we describe a genetically defined microglia sublineage in mice which has the ability to suppress obsessive compulsion and anxiety symptoms. These
David P Burns et al.
Experimental physiology, 102(9), 1177-1193 (2017-07-01)
What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our aim was to assess the effect of blocking interleukin-6 receptor signalling and
Patricia Tagliaferro et al.
The Journal of comparative neurology, 506(4), 616-626 (2007-12-11)
Interactions between stress and the mesocorticolimbic dopamine (DA) system have been suggested from behavioral and electrophysiological studies. Because corticotropin-releasing factor (CRF) plays a role in stress responses, we investigated possible interactions between neurons containing CRF and those producing DA in
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