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Merck

SRP5348

Sigma-Aldrich

GST protein, tag-free

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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About This Item

Numer CAS:
Kod UNSPSC:
12352202
NACRES:
NA.32

rekombinowane

expressed in E. coli

Próba

≥70% (SDS-PAGE)

Formularz

buffered aqueous glycerol solution

masa cząsteczkowa

~25 kDa

metody

ligand binding assay: suitable

numer dostępu NCBI

Warunki transportu

dry ice

temp. przechowywania

−70°C

informacje o genach

Escherichia coli IAI39 ... gst> gst
gst(7152360)

Opis ogólny

Glutathione S-transferase (GST) family of enzymes comprises a long list of cytosolic, mitochondrial and microsomal proteins that are used to create the so-called GST gene fusion system. These proteins are capable of multiple reactions with a multitude of substrates. They have a role in detoxication and toxification mechanisms. GST tag has the size of 220 amino acids, which is relatively large compared to other tags like the myc- or the FLAG-tag that are quite small. GST can be used to purify and detect proteins of interest. In a GST gene fusion system, an expression vector consists of the gene sequence encoding the protein of interest and GST sequence alongside. After induction, the fusion proteins can be purified using affinity chromatography via its high affinity for glutathione.

Zastosowanie

GST protein, tag-free has been used in in vitro F-actin binding assay. It has also been used as a protein tag for TPX2 (targeting protein for Xklp2).

Postać fizyczna

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Italia Anna Asteriti et al.
Oncotarget, 8(19), 32117-32133 (2017-04-09)
Aurora kinases are a family of cell division regulators that govern the correct assembly of a bipolar mitotic spindle and the fidelity of chromosome segregation. Their overexpression is associated with genomic instability and aneuploidy, and is frequently observed in cancer.
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
Calvo F
Cell Reports, 13(12), 2699-2714 (2015)
Duong Thi Thuy Nguyen et al.
Cell death and differentiation, 24(6), 1063-1078 (2017-04-22)
Rapidity and specificity are characteristic features of proteolysis mediated by the ubiquitin-proteasome system. Therefore, the UPS is ideally suited for the remodeling of the embryonic stem cell proteome during the transition from pluripotent to differentiated states and its inverse, the
Identification of small molecule inhibitors of the Aurora-A/TPX2 complex
Asteriti IA, et al.
Testing, 8(12), 32117-32117 (2017)
Yujing Li et al.
Nature communications, 9(1), 4394-4394 (2018-10-24)
Heterozygous deletion of chromosome 17p (17p) is one of the most frequent genomic events in human cancers. Beyond the tumor suppressor TP53, the POLR2A gene encoding the catalytic subunit of RNA polymerase II (RNAP2) is also included in a ~20-megabase

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